2023 in Evaluation
Health And Wellness Research + Innovation: A Turning Point
Palantir Foundry has actually long contributed in increasing the study searchings for of our health and life science companions, assisting attain extraordinary understandings, simplify data access, enhance information functionality, and facilitate innovative visualization and evaluation of data sources– all while protecting the personal privacy and safety and security of the support data
In 2023, Foundry sustained over 50 peer-reviewed magazines in prestigious journals, covering a varied variety of subjects– from healthcare facility procedures, to oncological medications, to discovering methods. The year prior, our software application supported a document number of peer-reviewed magazines, which we highlighted in a prior article
Our partners’ fundamental investments in technical facilities throughout the optimal of the COVID- 19 pandemic has actually made the outstanding amount of magazines possible.
Public and industrial healthcare partners have actually proactively scaled their investments in information sharing and research study software program beyond COVID response to build a much more comprehensive information structure for biomedical study. For instance, the N 3 C Enclave — which houses the data of 21 5 M clients from throughout almost 100 establishments– is being made use of daily by thousands of scientists across companies and companies. Offered the intricacy of accessing, arranging, and using ever-expanding biomedical data, the demand for similar research resources remains to climb.
In this blog post, we take a closer consider some significant publications from 2023 and analyze what lies in advance for software-backed study.
Arising Technology and the Acceleration of Scientific Study
The impact of new innovations on the clinical venture is accelerating research-based outcomes at a formerly impossible range. Emerging innovations and advanced software application are assisting produce extra accurate, arranged, and obtainable data properties, which subsequently are permitting researchers to take on progressively complex scientific obstacles. Specifically, as a modular, interoperable, and versatile platform, Shop has been used to sustain a varied variety of scientific research studies with one-of-a-kind research functions, including AI-assisted therapeutics identification, real-world evidence generation, and a lot more.
In 2023, the industry has actually also seen a rapid growth in rate of interest around using Artificial Intelligence (AI)– and in particular, generative AI and huge language models (LLM)– in the wellness and life science domains. Alongside other core technological innovations (e.g., around information quality and usability), the possibility for AI-enabled software program to speed up clinical research is a lot more promising than ever before. As a commercial leader in AI-enabled software, Palantir has been at the forefront of searching for accountable, safe, and efficient means to use AI-enabled capabilities to sustain our companions throughout industries in accomplishing their most important goals.
Over the past year, Palantir software application aided drive vital parts of our companions’ research study and we stand prepared to continue interacting with our companions in federal government, industry, and civil culture to take on the most important difficulties in wellness and scientific research in advance. In the next area, we supply concrete instances of exactly how the power of software can aid advancement scientific research, highlighting some vital biomedical magazines powered by Foundry in 2023
2023 Publications Powered by Palantir Shop
In addition to a number of essential cancer cells and COVID therapy studies, Palantir Foundry also enabled brand-new searchings for in the more comprehensive area of research study technique. Below, we highlight a sample of several of the most impactful peer-reviewed write-ups published in 2023 that used Palantir Factory to assist drive their study.
Identifying new efficient medication mixes for multiple myeloma
- Publication : Cancer Letters
- Authors : Peat, T.J., Gaikwad, S.M., Dubois, W., Gyabaah-Kessie, N., Zhang, S., Gorjifard, S., Phyo, Z., Andres, M., Hughitt, V.K., Simpson, R.M., Miller, M.A., Girvin, A.T., Taylor, A., Williams, D., D’Antonio, N., Zhang, Y., Rajagopalan, A., Flietner, E., Wilson, K., Zhang, X., Shinn, P., Klumpp-Thomas, C., McKnight, C., Itkin, Z., Chen, L., Kazandijian, D., Zhang, J., Michalowski, A.M., Simmons, J.K., Keats, J., Thomas, C.J., Mock, B.A.
- Summary : Several myeloma (MM) is often immune to drug treatment, calling for ongoing expedition to identify new, reliable restorative combinations. In this research, scientists utilized high-throughput medicine screening to identify over 1900 compounds with activity against at least 25 of the 47 MM cell lines examined. From these 1900 substances, 3 61 million mixes were evaluated in silico, and pairs of compounds with very associated task throughout the 47 cell lines and various systems of action were chosen for additional evaluation. Especially, six (6 medication combinations were effective at 1 decreasing over-expression of a crucial healthy protein (MYC) that is commonly connected to the production of deadly cells and 2 enhanced expression of the p 16 protein, which can aid the body subdue tumor growth. Moreover, 3 (3 identified medication combinations increased opportunities of survival and reduced the growth of cancer cells, in part by minimizing task of paths associated with TGFβ/ SMAD signaling, which regulate the cell life cycle. These preclinical searchings for recognize potentially beneficial novel medicine mixes for challenging to deal with multiple myeloma.
New rank-based healthy protein classification method to improve glioblastoma therapy
- Publication : Cancers cells
- Authors : Tasci, E., Jagasia, S., Zhuge, Y., Sproull, M., Cooley Zgela, T., Mackey, M., Camphausen, K., Krauze, A.V.
- Recap : Glioblastomas, one of the most common kind of cancerous mind tumors, vary greatly, limiting the ability to analyze the organic aspects that drive whether glioblastomas will react to therapy. Nevertheless, information evaluation of the proteome– the entire collection of proteins that can be shared by the lump– can 1 deal non-invasive methods of identifying glioblastomas to assist notify therapy and 2 determine protein biomarkers related to interventions to evaluate action to treatment. In this research, scientists created and checked an unique rank-based weighting approach (“RadWise”) for healthy protein includes to aid ML formulas focus on the the most relevant variables that show post-therapy end results. RadWise offers a much more effective pathway to determine the proteins and functions that can be essential targets for treatment of these hostile, deadly lumps.
Identifying liver cancer subtypes most likely to respond to immunotherapy
- Magazine : Cell Reports Medication
- Authors : Budhu, A., Pehrsson, E.C., He, A., Goyal, L., Kelley, R.K., Dang, H., Xie, C., Monge, C., Tandon, M., Ma, L., Revsine, M., Kuhlman, L., Zhang, K., Baiev, I., Lamm, R., Patel, K., Kleiner, D.E., Hewitt, S.M., Tran, B., Shetty, J., Wu, X., Zhao, Y., Shen, T.W., Choudhari, S., Kriga, Y., Ylaya, K., Detector, A.C., Edmondson, E.F., Forgues, M., Greten, T.F., Wang, X.W.
- Summary : Liver cancer cells is a rising source of cancer cells fatalities in the United States. This research study investigated variant in patient results for a type of immunotherapy using immune checkpoint inhibitors. Researchers noted that specific molecular subtypes of cancer, specified by 1 the aggressiveness of cancer cells and 2 the microenvironment of the cancer cells, were linked to higher survival prices with immune checkpoint inhibitor treatment. Identifying these molecular subtypes can help physicians recognize whether a client’s special cancer is most likely to react to this kind of treatment, meaning they can apply more targeted use immunotherapy and boost possibility of success.
Applying formulas to EHR information to infer maternity timing for even more precise maternal wellness research study
- Publication : JAMIA, Women’s Health Special Edition
- Writers : Jones, S., Bradwell, K.R. *, Chan, L.E., McMurry, J.A., Olson-Chen, C., Tarleton, J., Wilkins, K.J., Qin, Q., Faherty, E.G., Lau, Y.K., Xie, C., Kao, Y.H., Liebman, M.N., Ljazouli, S. *, Mariona, F., Challa, A., Li, L., Ratcliffe, S.J., Haendel, M.A., Patel, R.C., Hillside, E.L.
- Recap : There are signs that COVID- 19 can cause maternity complications, and expecting individuals seem at greater danger for much more extreme COVID- 19 infection. Analysis of health and wellness record (EHR) data can aid offer even more insight, but as a result of data incongruities, it is usually challenging to establish 1 maternity start and end days and 2 gestational age of the infant at birth. To aid, researchers adjusted an existing algorithm for identifying gestational age and pregnancy size that depends on diagnostic codes and delivery days. To enhance the accuracy of this formula, the researchers layered by themselves data-driven formulas to exactly presume pregnancy start, pregnancy end, and spots amount of time throughout a pregnancy’s progression while likewise dealing with EHR information disparity. This technique can be dependably made use of to make the fundamental reasoning of maternity timing and can be put on future maternity and maternity research on subjects such as damaging maternity results and mother’s death.
A novel method for dealing with EHR data quality problems for medical encounters
- Publication : JAMIA
- Authors : Leese, P., Anand, A., Girvin, A. *, Manna, A. *, Patel, S., Yoo, Y.J., Wong, R., Haendel, M., Chute, C.G., Bennett, T., Hajagos, J., Pfaff, E., Moffitt, R.
- Recap : Scientific encounter data can be a rich resource for research, yet it frequently varies considerably throughout service providers, facilities, and organizations, making it challenging to consistently assess. This variance is multiplied when multisite digital health and wellness record (EHR) information is networked with each other in a main database. In this study, scientists created a novel, generalizable approach for dealing with clinical experience information for evaluation by integrating associated encounters right into composite “macrovisits.” This approach assists control and deal with EHR encounter information issues in a generalizable, repeatable means, permitting scientists to more easily unlock the capacity of this abundant information for large studies.
Improving transparency in phenotyping for Long COVID research and beyond
- Publication : Journal of the American Medical Informatics Organization
- Authors : Pfaff, E.R., Girvin, A.T. *, Crosskey, M., Gangireddy, S., Master, H., Wei, W.Q., Kerchberger, V.E., Weiner, M., Harris, P.A., Basford, M., Lunt, C., Chute, C.G., Moffitt, R.A., Haendel, M.; N 3 C and RECOVER Consortia
- Summary : Phenotyping, the procedure of assessing and categorizing a microorganism’s features, can aid scientists much better comprehend the distinctions between people and groups of individuals, and to recognize details qualities that may be linked to specific conditions or conditions. Artificial intelligence (ML) can help derive phenotypes from information, but these are challenging to share and replicate due to their complexity. Scientists in this study devised and educated an ML-based phenotype to determine clients very possible to have Lengthy COVID, a significantly immediate public health and wellness consideration, and showed applicability of this approach for other settings. This is a success story of just how clear innovation and collaboration can make phenotyping formulas a lot more obtainable to a broad target market of scientists in informatics, minimizing copied job and giving them with a tool to get to understandings quicker, consisting of for various other illness.
Navigating challenges for multisite real life information (RWD) data sources
- Magazine : BMC Medical Research Method
- Authors : Sidky, H., Young, J.C., Girvin, A.T. *, Lee, E., Shao, Y.R., Hotaling, N., Michael, S., Wilkins, K.J., Setoguchi, S., Funk, M.J.; N 3 C Consortium
- Recap : Collaborating with huge range systematized EHR databases such as N 3 C for research calls for specialized understanding and careful assessment of information top quality and efficiency. This research analyzes the procedure of assessing data top quality in preparation for research, focusing on medication effectiveness studies. Scientist determined several methods and best methods to better characterize vital research components consisting of exposure to therapy, standard wellness comorbidities, and essential outcomes of passion. As big scale, streamlined real world data sources end up being extra widespread, this is a handy advance in assisting scientists more effectively navigate their one-of-a-kind data obstacles while opening crucial applications for medicine growth.
What’s Next for Health And Wellness Research Study at Palantir
While 2023 saw vital progression, the brand-new year brings with it new opportunities, as well as a necessity to use the latest technical developments to the most crucial wellness issues encountering individuals, communities, and the general public at huge. As an example, in 2023, the united state Government declared its dedication to combating systemic diseases such as cancer, and also released a new health and wellness company, the Advanced Research Projects Company for Health ( ARPA-H
Additionally, in 2024, Palantir is proud to be an industry companion in the innovative National AI Research Source (NAIRR) pilot program , produced under the auspices of the National Science Structure (NSF) and with financing from the NIH. As component of the NAIRR pilot– whose launch was routed by the Biden Management’s Executive Order on Artificial Intelligence — Palantir will certainly be collaborating with its veteran partners at the National Institutes of Health (NIH) and N 3 C to support research study ahead of time risk-free, safe and secure, and reliable AI, along with the application of AI to obstacles in healthcare.
In 2024, we’re thrilled to deal with partners, brand-new and old, on concerns of vital significance, using our discoverings on information, tools, and research study to aid allow purposeful improvements in wellness results for all.
For more information concerning our proceeding work across health and wellness and life sciences, browse through https://www.palantir.com/offerings/federal-health/
* Authors connected with Palantir Technologies